Dr. Kauwe is an Associate Professor and Associate Department Chair of Biology at Brigham Young University. He specializes in processing and analysis of genetic data and has published over 100 peer reviewed papers. Dr. Kauwe recently served a panelist for the NIH Summit on Alzheimer’s disease and as the Scientific Lead for the SAGE AD Challenge. He is currently a Senior Editor for the journal Alzheimer’s & Dementia
His research leverages novel phenotypes and approaches to characterize the genetic architecture of Alzheimer’s disease with the ultimate goal of finding a cure.
Contact Dr. Kauwe
4146 LSB Provo, UT 84602
Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by gradual onset and progression of memory loss combined with deficits in executive functioning, language, visuo-spatial abilities, personality, behavior and self-care.Citing the rapid growth of the oldest age groups in the U.S. population, recent studies predict a rapid increase in the prevalence of AD unless more effective treatments can be developed. Individuals with AD live from eight to more than 20 or years after the onset of symptoms, making this disease both emotionally and financially devastating. The national direct and indirect costs of caring for individuals with AD are in excess of 100 billion dollars. In order to diagnose AD earlier and treat it more efficiently, we must identify both the genetic and environmental factors, which modulate risk for disease.
We have funded projects that focus on genetics, proteomics, and small molecule drug development to solve AD.
NIH R01 PLEIOTROPIC AND INTERACTION EFFECTS ON ALZHEIMER'S DISEASE RISK AND PROGRESSION (PI, Dr. Kauwe)
The major goal of this project is to use genome-wide marker data to detect loci that simultaneously affect cerebospinal fluid amyloid beta and tau levels (pleiotropy), loci which modify the relationships between Alzheimer’s disease biomarkers (cerebrospinal fluid amyloid beta and tau) and Alzheimer’s disease (referred to as rQTL), and gene-by-gene interactions.
NIH R01 EPIDEMIOLOGY OF ALZHEIMER’S DISEASE RESILIENCE AND RISK PEDIGREES (PI, Dr. Kauwe)
The major goal of this project is to identify measurable risk and resilience factors for Alzheimer's disease, which will lead to better strategies for treatment and prevention of this devastating disease.